A superb strike from Ian Goodison and a late effort from Ian Thomas-Moore gave Rovers a 2-1 victory over Carlisle United and their first win of 2011.
An entertaining game at Prenton Park saw Carlisle miss a penalty and Tranmere have two saved, while Goodison's thunderbolt was the difference between the sides at half time. Carlisle looked to have rescued a point when James Berrett struck with a quarter of an hour remaining but Thomas-Moore netted from close range soon after to secure the win.
There were two changes to the side that started at Rochdale as Rovers opted for a 4-4-2 formation, with Dale Jennings returning to the left side of midfield in place of Ash Taylor and Tim Cathalina coming in for the suspended Marlon Broomes and Scott Wootton moving to centre back. Former Rovers striker Craig Curran started the match for Carlisle.
Rovers comfortably dealt with a Carlisle corner inside the first minute while an Aaron Cresswell free kick landed harmlessly wide of the far post on five minutes.
Enoch Showunmi shot wide from the edge of the area a minute later but his effort wouldn't have counted had it gone in as a free kick was awarded against the forward for handball.
A shot from Curran struck Wootton in the face on nine minutes, the Manchester United youngster inadvertently blocking a goal bound effort, while Gary Madine headed over from Ben Marshall's cross soon after.
Joss Labadie fired a 35 yard free kick over Adam Collin's goal on ten minutes and moments later it needed a well timed touch from Ian Goodison to prevent Madine from breaking the deadlock at the other end.
On 16 minutes it looked like the visitors were set to take the lead when a penalty was awarded against Cathalina at a Carlisle corner, but the score remained level as Peter Murphy wasted the opportunity as he sent his left foot effort high over Joe Collister's bar.
Thomas-Moore sent a low curling effort into the arms of Collin after persistent play from Elford-Alliyu on the edge of the Carlisle area.
Enoch Showunmi beat his man to meet Jennings' floated cross on 23 minutes but his header went over the bar from eight yards out.
For a moment it appeared that the Cumbrians were to be awarded a second penalty on 26 minutes when James Berrett went down under a challenge from Goodison but rather than point to the spot, referee Dave Foster showed the Carlisle midfielder a yellow card for diving.
Marshall sent a rising volley over the bar on 31 minutes while Labadie missed with a side footer from an Aaron Cresswell corner seven minutes later. However, the visitors didn't clear the ball and moments later it fell to Goodison just outside the area who rifled in a wonderful low shot which struck the inside of the left hand post and went into the Carlisle goal.
Lubomir Michalik headed over from a corner as Greg Abbott's side looked for a quick response but it proved to be the last chance of the half as Rovers took their lead into the break.
Collister kept Rovers ahead in the third minute of the second half, producing a fine dive and one handed save to keep out Madine's side footed close range shot.
The young keeper pulled off another decent save from Curran's half volley on 52 minutes, while Thomas-Moore was ruled offside just as he was about to shoot at the other end.
Rovers were given a chance to double their lead on 59 minutes with the award of a penalty. A well worked corner saw Jennings step over Cresswell's pass and the ball go to Labadie. Rather than shoot the midfielder took a touch and was brought down by Matt Robson. For the second time in three days Thomas-Moore was on spot kick duties but this time Collin guessed correctly and palmed his effort away to safety. It was the fourth penalty in the two games between Tranmere and Carlisle in 2010-11, with none of them finding the net.
Showunmi did well to charge down Collin's clearance on 66 minutes but fortunately for the Carlisle keeper the ball rebounded straight to Robson wide on the right.
Rovers were given another penalty on 69 minutes, this time Elford-Alliyu racing into the Carlisle area, seeing his shot blocked only for the ball to rebound straight to him and Frank Simek take his legs from underneath him. This time Cresswell stepped up to take the penalty but his drive straight down the middle was also kept out by the hand of Collin.
A dangerous ball from Carlisle substitute Francois Zoko went straight through the Rovers six yard box and out the other side on 74 minutes but five minutes later the visitors drew level. After Goodison failed to clear the ball, it was played back into the box and Berrett turned past Collister with a low shot from ten yards.
At the other end a Labadie shot was only parried by Collin but Elford-Alliyu's cross back into the box was cut out by Robson. However, a minute later Tranmere regained the lead. Jennings' pass found Showunmi out wide and his ball into the box wasn't cleared by the Carlisle defence allowing Thomas-Moore to smash in from eight yards.
The injured Cathalina was replaced by Max Blanchard with five minutes remaining while Showunmi shot wide on the turn after good work from Thomas-Moore and Jennings.
Jennings sent a low shot straight at Collin on 90 minutes after being found by Showunmi while appeals for another penalty from Thomas-Moore were waved away from the referee seconds later.
Grella fired high and wide in the first of five minutes of injury time after excellent work down the left from Marshall for Carlisle and the visitors sent a free kick straight into the wall soon after, their final chance of the game.
Tranmere: Collister, Cathalina (Blanchard 85), Wootton, Goodison, Cresswell, Elford-Alliyu, Welsh, Labadie, Jennings, Showunmi, Thomas-Moore. Substitutes not used: Miotto, Bakayogo, Taylor, Fraughan, Akins, McGurk.
Carlisle: Collin, Simek, Murphy, Robson (Bowman 89), Thirlwell, Taiwo (Grella 65), Marshall, Curran (Zoko 56), Madine, Berrett, Michalik. Substitutes not used: Hurst, Caig, Cruise, Eastham.
Referee: Dave Foster
Yellow cards: Michalik (12), Berrett (27), Thirlwell (57), Taiwo (63), Cathalina (71)
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