Tranmere recorded their biggest ever away win over Leyton Orient as two goals from Adam McGurk and a long range strike from Aaron Cresswell earned them a 3-0 victory at the Matchroom Stadium.
The result ended the hosts' hopes of reaching the League 1 play-offs and lifted Tranmere to 56 points and up to 15th place in the table. It was Les Parry's side's fourth win in six games and second clean sheet in a row.
There was just one change to the side that started the 4-0 win over Exeter, as Adam McGurk came in for the injured Enoch Showunmi. Mark McChrystal was named among the substitutes after missing the Exeter game through injury, while there was no place among the Leyton Orient line up for former Tranmere defender Ben Chorley.
Andy Robinson forced a corner in the second minute from which McGurk headed over the bar from an unmarked position at the far post.
Rovers continued their bright start when Aaron Cresswell tested Jamie Jones with a powerfully struck free kick from 35 yards and again the Orient keeper could only turn it behind for a corner.
From the set piece that followed Les Parry's side took the lead. The ball was played from McGurk to Cresswell who, 30 yards out, smashed a left foot shot high past Jones into the roof of the net.
Cresswell proved just as useful at the other end moments later when he cleared Dean Cox's dangerous cross, while Robinson won another corner for Rovers after hitting the wall from a free kick and a looping header from Taylor was saved by Jones.
Dale Jennings fired wide from distance on 19 minutes and after a good run sent a cross straight through the Orient area and out the other side soon after.
Elliot Omozusi brought a save out of Tony Warner and Cox shot wide for Orient on 29 minutes but the action was soon back in the opposite half.
Jennings headed a Kay cross over the bar on 32 minutes as Tranmere continued to create the majority of the chances and the youngster sliced a shot wide from long range five minutes later.
Rovers' pressure paid off a second time on the stroke of half time. A strong tackle from Robbie Weir saw the ball find McGurk and the former Aston Villa striker raced towards goal and rolled his shot past Jones and into the bottom corner of the net for his second goal for the Club.
After Orient made a double change at the start of the second half McGurk brought a save out of Jones with a header straight at the keeper's body.
And four minute into the half Rovers went further ahead. A free kick for a foul on Robinson by Omozusi was whipped in by Cresswell and it bounced off the chest of McGurk and into the net.
A shot from Akins was blocked on its way to goal on 51 minutes and ten minutes later the former Huddersfield man moved into the central attacking role when McGurk was forced off through cramp, Joss Labadie coming on in his place.
Orient substitute Scott McGleish headed over Warner's bar on 64 minutes, five minutes before Zoumana Bakayogo replaced Jennings. The Frenchman almost added a fourth moments after coming on to the pitch, but his chip over Jones hit the post and rebounded to safety.
Warner kept out a Cox effort with his shoulder on 72 minutes and Bakayogo did well to clear soon after as the hosts put pressure on the Tranmere area. Three corners gave Russell Slade's side chances to bring themselves back into the game but the closest they came was Cox's header that went over the bar.
Max Blanchard came on for Robinson with 11 minutes of normal time remaining with the versatile midfielder taking up a holding midfield role next to John Welsh.
Though Orient spent much of the final ten minutes in the Rovers half, they were unable to test Warner as Tranmere ran out comfortable winners.
Leyton Orient: Jones, Omozusi, Forbes, Cox, Dawson, Chambers (McGleish 45HT), Daniels, Spring, Tehoue (Carroll 45 HT), Kane (Mpoku72), Barrett. Substitutes not used: Whing, Butcher, Jarvis, Crowe.
Tranmere: Warner, Kay, Taylor, Goodison, Cresswell, Weir, Welsh, Robinson (Blanchard 79), Akins, McGurk (Labadie 61), Jennings (Bakayogo 69). Substitutes not used: Coughlin, McChrystal, Wood, Mahon.
Referee: Graham Horwood
Yellow cards: Jennings (45+1), Omozusi (48), Labadie (88)
Away attendance: 331
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