Referee Tim Robinson will take charge of the npower League 1 fixture against Oldham Athletic at Prenton Park on Saturday.
The match will be Mr Robinson's first time in charge of Rovers as he only joined the Football League this season.
In 2012-13 he has refereed 22 games, showing 51 yellow cards and two reds. His last match in charge was Exeter's 3-0 win over Northampton in League 2.
The referee's assistants will be Joe Hull and Simeon Lucas with Phillip Dermott the fourth official.